Schmidt-Sarosi C L, Yerovi L A
Department of Obstetrics and Gynecology, New York University School of Medicine, New York.
Int J Fertil Menopausal Stud. 1994 Jan-Feb;39(1):20-5.
To compare the use of two gonadotropin-releasing hormone agonists, nafarelin acetate (NA) and leuprolide acetate (LA), in conjunction with human menopausal gonadotropins (hMG)/human chorionic gonadotropin (hCG) and intrauterine insemination (IUI).
Retrospective analysis of selected patient records. Patients were assigned to treatment groups systematically, but not randomly. Fixed rules were used for selection of medical records, but the study was not blinded.
University medical center ovulation induction program.
Fifteen NA/hMG/IUI cycles were analyzed in comparison with 15 contemporary LA/hMG/IUI cycles.
There were no differences in: the number of days to ovarian suppression, the number of ampules of hMG required, the number of 17-mm preovulatory follicles, or the mean peak estradiol levels. However, the minimum estradiol levels at the height of ovarian suppression by GnRH agonist were lower in the LA group than in the NA group. Furthermore, 4/15 NA cycles resulted in pregnancy compared with 0/15 LA cycles.
NA is, at the least, comparable to LA in effecting pregnancy after superovulation/IUI.
比较两种促性腺激素释放激素激动剂，醋酸那法瑞林（NA）和醋酸亮丙瑞林（LA），联合人绝经期促性腺激素（hMG）/人绒毛膜促性腺激素（hCG）及宫内人工授精（IUI）的应用情况。
对选定患者记录进行回顾性分析。患者被系统地而非随机地分配至治疗组。采用固定规则选择病历，但该研究未设盲。
大学医学中心排卵诱导项目。
分析了15个NA/hMG/IUI周期，并与15个同期的LA/hMG/IUI周期进行比较。
在以下方面无差异：卵巢抑制天数、所需hMG安瓿数量、直径17毫米的排卵前卵泡数量或平均雌二醇峰值水平。然而，在GnRH激动剂抑制卵巢期间，LA组的最低雌二醇水平低于NA组。此外，15个NA周期中有4个导致妊娠，而15个LA周期中无妊娠发生。
在超排卵/IUI后实现妊娠方面，NA至少与LA效果相当。
