Breitholtz-Emanuelsson A, Palminger-Hallén I, Wohlin P O, Oskarsson A, Hult K, Olsen M
Department of Biochemistry and Biotechnology, Royal Institute of Technology, Stockholm, Sweden.
Nat Toxins. 1993;1(6):347-52. doi: 10.1002/nt.2620010605.
A dose-dependent transfer of ochratoxin A into the milk of lactating rats was found after a single oral dose of ochratoxin A, given in the dose levels of 10, 50, and 250-micrograms ochratoxin A/kg body weight by gastric intubation. The milk/blood concentration ratio of ochratoxin A at 24 and 72 h was 0.4 and 0.7, respectively. A linear relationship was found between the concentration of ochratoxin A in the dam's milk and in the blood of the pups at 72 h, as well as in the dam's milk and in the kidneys of the pups. The pup blood/milk concentration ratio of ochratoxin A was approximately 6. At 72 h the sucklings had higher levels of ochratoxin A than their dams in both blood and kidneys. The results show that the concentration of ochratoxin A in milk can be used as an indicator of the continuously administered dose to the suckling.
