Vigabatrin: a three year clinical analysis.

The effect of introducing vigabatrin into the management of 57 patients with severe epilepsy is reported. Overall it reduced fit frequency by 50% or more in 36% of our patients. We found it to be more effective than previously reported for primary tonic-clonic seizures, but less so for complex partial seizures. Fewer of our patients withdrew from treatment due to adverse drug reactions than in earlier studies.