Martin P J, Millac P A
Department of Neurology, Leicester Royal Infirmary, UK.
Seizure. 1993 Jun;2(2):137-40. doi: 10.1016/s1059-1311(05)80118-9.
The effect of introducing vigabatrin into the management of 57 patients with severe epilepsy is reported. Overall it reduced fit frequency by 50% or more in 36% of our patients. We found it to be more effective than previously reported for primary tonic-clonic seizures, but less so for complex partial seizures. Fewer of our patients withdrew from treatment due to adverse drug reactions than in earlier studies.
报告了将氨己烯酸引入57例严重癫痫患者治疗中的效果。总体而言，36%的患者癫痫发作频率降低了50%或更多。我们发现它对原发性强直阵挛性发作比之前报道的更有效，但对复杂部分性发作效果较差。与早期研究相比，因药物不良反应退出治疗的患者更少。
