Ra'anani P, Shpilberg O, Berezin M, Ben-Bassat I
Institute of Hematology, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
Cancer. 1994 May 1;73(9):2312-6. doi: 10.1002/1097-0142(19940501)73:9<2312::aid-cncr2820730912>3.0.co;2-i.
Diabetes insipidus due to leukemic involvement of the central nervous system has been described previously in several patients. Although the timing of the diabetes insipidus onset in relation to the leukemia is variable, it has not been described previously as the first manifestation of leukemia relapse.
Two cases of leukemia relapse presenting as central diabetes insipidus are described and the literature is reviewed.
Clinical data of 29 of the 39 reported cases were available. The median age was 46 years, with no gender predominance. Seventy-three percent had acute nonlymphocytic leukemia, and deletion of chromosome 7 or monosomy 7 was the predominant cytogenetic abnormality. No temporal relation between the onset of diabetes insipidus and the leukemia was found. In none of the previously reported cases was diabetes insipidus the first manifestation of the leukemia recurrence.
The temporal relationship between diabetes insipidus and leukemia is inconsistent. The former may precede, follow, or present concomitantly with the latter. Two cases of diabetes insipidus as the presenting sign of leukemia relapse are reported.
中枢神经系统白血病浸润导致的尿崩症此前已在数例患者中有所描述。尽管尿崩症发病时间与白血病的关系存在差异，但此前尚未将其描述为白血病复发的首发表现。
描述了2例以中枢性尿崩症为表现的白血病复发病例，并对文献进行了综述。
39例报告病例中有29例的临床数据可用。中位年龄为46岁，无性别优势。73%患有急性非淋巴细胞白血病，7号染色体缺失或单体7是主要的细胞遗传学异常。未发现尿崩症发病与白血病之间存在时间关系。在之前报道的病例中，无一例尿崩症是白血病复发的首发表现。
尿崩症与白血病之间的时间关系不一致。前者可能先于、后于或与后者同时出现。报告了2例以尿崩症为白血病复发首发体征的病例。
