Raziuddin S, Sheikha A, Abu-Eshy S, al-Janadi M
Department of Clinical Immunology, King Saud University, College of Medicine, Abha, Saudi Arabia.
Cancer. 1994 May 1;73(9):2426-31. doi: 10.1002/1097-0142(19940501)73:9<2426::aid-cncr2820730928>3.0.co;2-k.
Cytokines, interleukin (IL)-4, IL-6, interferon-gamma (IFN-gamma), tumor necrosis factor-alpha (TNF-alpha), soluble CD23 (sCD23), and soluble IL-2 receptors (sIL-2R) are mediators of inflammation and immune response. Alterations in immune status of patients with various cancers may result in release of cytokines in circulation. The authors measured the circulating levels of IL-4, IL-6, IFN-gamma, TNF-alpha, sCD23, and sIL-2R from patients with T-cell chronic lymphocytic leukemia (T-CLL), T-cell acute lymphoblastic leukemia (T-ALL) and peripheral T-cell lymphoma (PTCL) to determine their importance in these T-cell disorders.
IL-4, IL-6, IFN-gamma, TNF-alpha, sCD23, and sIL-2R levels were measured from the serum samples by enzyme-linked immunosorbent assay or bioassay methods.
IL-4 levels were higher only in T-CLL, whereas, IFN-gamma and sIL-2R levels were higher in T-CLL and T-ALL. However, IL-6, TNF-alpha, and sCD23 levels were higher in PTCL.
T-cell-derived IL-4 and IFN-gamma in T-CLL may act as an autocrine growth factor for proliferation of neoplastic T-cells. The sIL-2R levels in T-CLL, T-ALL, and PTCL are an indication of the degree of T-cell or immune activation due to concomitant immunologic processes in these disorders. However, IL-6, TNF-alpha, and sCD23 levels may contribute to inflammatory response and provide evidence of monocyte/macrophage, T-cell, or B-cell aberrations in PTCL.
细胞因子，如白细胞介素（IL）-4、IL-6、干扰素-γ（IFN-γ）、肿瘤坏死因子-α（TNF-α）、可溶性CD23（sCD23）和可溶性IL-2受体（sIL-2R）是炎症和免疫反应的介质。各种癌症患者免疫状态的改变可能导致细胞因子在循环中释放。作者检测了T细胞慢性淋巴细胞白血病（T-CLL）、T细胞急性淋巴细胞白血病（T-ALL）和外周T细胞淋巴瘤（PTCL）患者循环中IL-4、IL-6、IFN-γ、TNF-α、sCD23和sIL-2R的水平，以确定它们在这些T细胞疾病中的重要性。
采用酶联免疫吸附测定法或生物测定法检测血清样本中IL-4、IL-6、IFN-γ、TNF-α、sCD23和sIL-2R的水平。
IL-4水平仅在T-CLL中较高，而IFN-γ和sIL-2R水平在T-CLL和T-ALL中较高。然而，IL-6、TNF-α和sCD23水平在PTCL中较高。
T-CLL中T细胞来源的IL-4和IFN-γ可能作为肿瘤性T细胞增殖的自分泌生长因子。T-CLL、T-ALL和PTCL中的sIL-2R水平表明了这些疾病中伴随免疫过程导致的T细胞或免疫激活程度。然而，IL-6、TNF-α和sCD23水平可能有助于炎症反应，并为PTCL中单核细胞/巨噬细胞、T细胞或B细胞异常提供证据。
