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Opsonization of Staphylococcus aureus by bovine immunoglobulin isotypes.牛免疫球蛋白同种型对金黄色葡萄球菌的调理作用。
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Identification and disruption of two discrete loci encoding hyaluronic acid capsule biosynthesis genes hasA, hasB, and hasC in Streptococcus uberis.在乳房链球菌中鉴定并破坏了两个编码透明质酸荚膜生物合成基因的离散基因座,即hasA、hasB和hasC。
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The hyaluronic acid capsule of Streptococcus uberis is not required for the development of infection and clinical mastitis.乳房链球菌的透明质酸荚膜对于感染和临床乳腺炎的发生并非必需。
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8
Identification and disruption of two discrete loci encoding hyaluronic acid capsule biosynthesis genes hasA, hasB, and hasC in Streptococcus uberis.在乳房链球菌中鉴定并破坏了两个编码透明质酸荚膜生物合成基因的离散基因座,即hasA、hasB和hasC。
Infect Immun. 2001 Jan;69(1):392-9. doi: 10.1128/IAI.69.1.392-399.2001.
9
Local vaccination with killed Streptococcus uberis protects the bovine mammary gland against experimental intramammary challenge with the homologous strain.用灭活的乳房链球菌进行局部接种可保护牛乳腺免受同源菌株的实验性乳房内攻击。
Infect Immun. 1994 Sep;62(9):3599-603. doi: 10.1128/iai.62.9.3599-3603.1994.

本文引用的文献

1
Current knowledge of type-specific M antigens of group A streptococci.A组链球菌特定类型M抗原的现有知识。
J Immunol. 1962 Sep;89:307-13.
2
MOTION PICTURE STUDY OF THE TOXIC ACTION OF STREPTOLYSINS ON LEUCOCYTES.链球菌溶血素对白细胞毒性作用的电影研究
J Exp Med. 1963 Aug 1;118(2):223-8. doi: 10.1084/jem.118.2.223.
3
STUDIES ON LYSOSOMES. III. THE EFFECTS OF STREPTOLYSINS O AND S ON THE RELEASE OF ACID HYDROLASES FROM A GRANULAR FRACTION OF RABBIT LIVER.溶酶体研究。III. 链球菌溶血素O和S对兔肝颗粒组分中酸性水解酶释放的影响。
J Exp Med. 1963 Aug 1;118(2):205-22. doi: 10.1084/jem.118.2.205.
4
Surface receptors for immunoglobulin on bovine polymorphonuclear neutrophils and macrophages.牛多形核中性粒细胞和巨噬细胞上免疫球蛋白的表面受体。
Res Vet Sci. 1980 Jul;29(1):128-30.
5
Binding of human immunoglobulin G to protein A in encapsulated Staphylococcus aureus.人免疫球蛋白G与包膜金黄色葡萄球菌中蛋白A的结合。
Infect Immun. 1981 Sep;33(3):666-72. doi: 10.1128/iai.33.3.666-672.1981.
6
Tropomyosin-like seven residue periodicity in three immunologically distinct streptococal M proteins and its implications for the antiphagocytic property of the molecule.三种免疫特性不同的链球菌M蛋白中类似原肌球蛋白的七残基周期性及其对该分子抗吞噬特性的影响。
J Exp Med. 1980 Mar 1;151(3):695-708. doi: 10.1084/jem.151.3.695.
7
Influence of the Escherichia coli capsule on complement fixation and on phagocytosis and killing by human phagocytes.大肠杆菌荚膜对补体结合以及对人类吞噬细胞吞噬和杀伤作用的影响。
J Clin Invest. 1980 Jan;65(1):82-94. doi: 10.1172/JCI109663.
8
A role for IgM in the in vitro opsonisation of Staphylococcus aureus and Escherichia coli by bovine polymorphonuclear leucocytes.IgM在牛多形核白细胞对金黄色葡萄球菌和大肠杆菌的体外调理作用中的作用。
Res Vet Sci. 1982 Jul;33(1):47-53.
9
Reviews of the progress of dairy science: mastitis control--progress and prospects.乳品科学进展综述:乳腺炎防治——进展与展望
J Dairy Res. 1984 Aug;51(3):481-512. doi: 10.1017/s0022029900023797.
10
Differences in anti-protein A activity among IgG subgroups.IgG亚组间抗蛋白A活性的差异。
J Immunol. 1969 Oct;103(4):828-33.

乳房链球菌能抵抗牛中性粒细胞的杀菌作用,尽管存在结合的免疫球蛋白。

Streptococcus uberis resists the bactericidal action of bovine neutrophils despite the presence of bound immunoglobulin.

作者信息

Leigh J A, Field T R

机构信息

Institute for Animal Health, Compton Laboratory, Newbury, Berks, United Kingdom.

出版信息

Infect Immun. 1994 May;62(5):1854-9. doi: 10.1128/iai.62.5.1854-1859.1994.

DOI:10.1128/iai.62.5.1854-1859.1994
PMID:8168949
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC186426/
Abstract

Streptococcus uberis 0140J was more resistant to the bactericidal action of bovine neutrophils after growth in chemically defined medium (CDM) supplemented with casein hydrolysate than when grown in CDM alone. Neither adult bovine serum obtained prior to vaccination nor hyperimmune serum raised against this bacterium was capable of acting as an effective opsonin towards S. uberis grown in the presence of casein hydrolysate. There was no detectable difference in the ability of bacteria grown in either CDM or CDM supplemented with casein hydrolysate to bind immunoglobulin G1 (IgG1), IgG2, or IgM from either hyperimmune serum or preparations of immunoglobulin from the same serum. Bacteria of both the phagocytosis-resistant and phagocytosis-sensitive phenotypes presented the same amount of IgG2 Fc terminus on their surfaces. It is concluded that the inducible resistance of S. uberis to bactericidal action of bovine neutrophils is not mediated by inhibition of antibody binding.

摘要

与仅在化学限定培养基(CDM)中生长相比,乳房链球菌0140J在添加酪蛋白水解物的CDM中生长后,对牛中性粒细胞的杀菌作用更具抗性。接种前获得的成年牛血清或针对该细菌产生的超免疫血清,均不能作为酪蛋白水解物存在时生长的乳房链球菌的有效调理素。在CDM或添加酪蛋白水解物的CDM中生长的细菌,结合来自超免疫血清或同一血清免疫球蛋白制剂中的免疫球蛋白G1(IgG1)、IgG2或IgM的能力,没有可检测到的差异。抗吞噬和吞噬敏感表型的细菌在其表面呈现相同数量的IgG2 Fc末端。得出的结论是,乳房链球菌对牛中性粒细胞杀菌作用的诱导抗性不是由抗体结合的抑制介导的。