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Characterization of the type I secretion system of the RTX toxin ApxII in "Actinobacillus porcitonsillarum".猪扁桃体放线杆菌中RTX毒素ApxII的I型分泌系统的特性分析
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Association of the CAMP phenomenon in Actinobacillus pleuropneumoniae with the RTX toxins ApxI, ApxII and ApxIII.胸膜肺炎放线杆菌中CAMP现象与RTX毒素ApxI、ApxII和ApxIII的关联。
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Identification of hemolytic and cytotoxic proteins of Actinobacillus pleuropneumoniae by use of monoclonal antibodies.利用单克隆抗体鉴定胸膜肺炎放线杆菌的溶血蛋白和细胞毒性蛋白
Infect Immun. 1991 Sep;59(9):3079-85. doi: 10.1128/iai.59.9.3079-3085.1991.

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Polymorphism analysis of the apxIA gene of Actinobacillus pleuropneumoniae serovar 5 isolated in swine herds from Brazil.对巴西猪群分离的胸膜肺炎放线杆菌 5 型 apxIA 基因的多态性分析。
PLoS One. 2018 Dec 18;13(12):e0208789. doi: 10.1371/journal.pone.0208789. eCollection 2018.
2
Acylation of Escherichia coli hemolysin: a unique protein lipidation mechanism underlying toxin function.大肠杆菌溶血素的酰化作用：毒素功能背后独特的蛋白质脂化机制。
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Molecular analysis of the Actinobacillus pleuropneumoniae RTX toxin-III gene cluster.胸膜肺炎放线杆菌RTX毒素III基因簇的分子分析。
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Cloning and characterization of a hemolysin gene from Actinobacillus (Haemophilus) pleuropneumoniae.胸膜肺炎放线杆菌（溶血嗜血杆菌）溶血素基因的克隆与特性分析
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TolC, an Escherichia coli outer membrane protein required for hemolysin secretion.TolC，一种溶血素分泌所需的大肠杆菌外膜蛋白。
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7
Activation of Escherichia coli prohaemolysin to the mature toxin by acyl carrier protein-dependent fatty acylation.通过酰基载体蛋白依赖性脂肪酰化作用将大肠杆菌前溶血素激活为成熟毒素。
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Pore-forming cytolysins of gram-negative bacteria.革兰氏阴性菌的成孔细胞溶素
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In vitro activation of Escherichia coli prohaemolysin to the mature membrane-targeted toxin requires HlyC and a low molecular-weight cytosolic polypeptide.
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Identification of RTX toxin target cell specificity domains by use of hybrid genes.利用杂交基因鉴定RTX毒素的靶细胞特异性结构域
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胸膜肺炎放线杆菌ApxIIA毒素的细胞毒性和溶血活性的差异表达

Differential expression of the cytotoxic and hemolytic activities of the ApxIIA toxin from Actinobacillus pleuropneumoniae.

作者信息

Tu A H, Hausler C, Young R, Struck D K

机构信息

Department of Medical Biochemistry and Genetics, Texas A&M Health Science Center, College of Medicine, College Station 77843-1114.

出版信息

Infect Immun. 1994 May;62(5):2119-21. doi: 10.1128/iai.62.5.2119-2121.1994.

DOI:10.1128/iai.62.5.2119-2121.1994
PMID:8168980
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC186478/
Abstract

The ApxIIA protein secreted from Actinobacillus pleuropneumoniae is both hemolytic and cytotoxic. However, when the cloned apxII operon is expressed in Escherichia coli, two forms of the ApxIIA protein can be recovered. Toxin which remains intracellular has hemolytic and cytotoxic activities, while toxin that is secreted is cytotoxic with little or no hemolytic activity. This indicates that the cytotoxicity of ApxIIA is independent of its hemolytic activity.

摘要

胸膜肺炎放线杆菌分泌的ApxIIA蛋白具有溶血活性和细胞毒性。然而，当克隆的apxII操纵子在大肠杆菌中表达时，可以获得两种形式的ApxIIA蛋白。保留在细胞内的毒素具有溶血活性和细胞毒性，而分泌的毒素具有细胞毒性，但溶血活性很小或没有。这表明ApxIIA的细胞毒性与其溶血活性无关。