Randall D C, Brown D R
Department of Physiology and Biophysics, College of Medicine, University of Kentucky, Lexington 40536-0084.
J Exp Anal Behav. 1994 Mar;61(2):273-9. doi: 10.1901/jeab.1994.61-273.
Brady and colleagues have championed the importance of careful delineation and control of a subject's behavioral state. In this paper we develop the concept of visceral behavior from a physiological perspective. Sprague-Dawley rats were instrumented to record arterial blood pressure, renal sympathetic nerve activity, and respiration. The rats were restrained in a conical cloth sock. Rats that were well adapted to the sock restraint showed a regular respiratory pattern and consistent pressure recordings; they rested quietly in the sock and moved only occasionally to adjust their position. Fourier analysis of blood pressure and nerve activity showed a concentration of power below 1 Hz. The coherence between the two signals was strong (0.83 +/- 0.03) at 0.42 Hz. Conversely, during their initial adjustment to the sock restraint, the rats tended to show large fluctuations in blood pressure associated with episodic apneic breathing; 1 animal displayed this pattern of visceral behavior throughout most of the experiment. Despite this instability in pressure, the rats' overt behavior was stable: They rested quietly in the sock with only occasional position shifts. Spectral analysis and coherence computations showed large shifts in the distribution of power and frequency range over which arterial pressure and sympathetic activity were tightly coupled. These data are consistent with the view that an animal's circulatory adjustments, as well as adjustments in other aspects of its physiological state, constitute an important aspect of behavior, and that this behavior can influence the interpretation of biobehavioral data.
布雷迪及其同事一直强调仔细界定和控制实验对象行为状态的重要性。在本文中，我们从生理学角度阐述了内脏行为的概念。对斯普拉格-道利大鼠进行仪器安装，以记录动脉血压、肾交感神经活动和呼吸情况。大鼠被束缚在一个锥形布套内。适应了布套束缚的大鼠呈现出规律的呼吸模式和稳定的血压记录；它们安静地躺在布套里，只是偶尔移动一下以调整姿势。对血压和神经活动进行傅里叶分析显示，功率集中在1赫兹以下。在0.42赫兹时，这两个信号之间的相干性很强（0.83±0.03）。相反，在最初适应布套束缚的过程中，大鼠往往会出现与间歇性呼吸暂停相关的血压大幅波动；有1只动物在整个实验的大部分时间里都表现出这种内脏行为模式。尽管血压不稳定，但大鼠的明显行为是稳定的：它们安静地躺在布套里，只是偶尔变换一下姿势。频谱分析和相干性计算表明，动脉血压和交感神经活动紧密耦合的功率分布和频率范围发生了很大变化。这些数据与以下观点一致，即动物的循环系统调节以及其生理状态其他方面的调节构成了行为的一个重要方面，而且这种行为会影响对生物行为数据的解读。
