Hernández-Beriaín J A, González T, Bustabad S, Gantes M, Rodríguez-Lozano B
Servicio de Reumatología, Hospital Universitario de Canarias, Facultad de Medicina, Universidad de La Laguna, Santa Cruz de Tenerife.
Med Clin (Barc). 1994 Feb 26;102(7):246-9.
To study the clinical activity of systemic lupus erythematosus (SLE) in recipients of renal transplants (rT) performed by terminal renal failure (TRF) secondary to lupus nephritis.
The clinical evolution of 11 patients with SLE (ARA criteria) and TRF were evaluated with a descriptive character by the modified index of activity SLE-DAI during dialysis periods and post rT as well as in the course prior to disease. A comparative analysis was carried out in a control group of 25 patients with SLE without renal failure.
The indexes of activity of the group investigated were higher than those of the control group during the predialysis period, similar in the dialysis period and significantly decreased (p < 0.01) in the post rT. In the group with rT a significant decrease was reported in the indexes of activity in the periods of dialysis (p < 0.05) and post rT (p < 0.01) with respect to the previous period. A significant reduction was observed in the post rT therapeutic options.
The clinical activity of systemic lupus erythematosus is reduced in the terminal renal failure in dialysis. The most significant reduction of clinical activity is found after renal transplantation.
研究因狼疮性肾炎继发终末期肾衰竭（TRF）而行肾移植（rT）受者系统性红斑狼疮（SLE）的临床活动情况。
采用改良的SLE疾病活动指数（SLE-DAI），对11例符合SLE（美国风湿病学会标准）且患有TRF的患者在透析期、肾移植后以及疾病发生前的病程进行描述性评估。对25例无肾衰竭的SLE患者组成的对照组进行对比分析。
研究组的活动指数在透析前期高于对照组，透析期相似，肾移植后显著降低（p<0.01）。肾移植组在透析期（p<0.05）和肾移植后（p<0.01）的活动指数相较于前一时期均有显著下降。肾移植后的治疗选择显著减少。
终末期肾衰竭透析患者的系统性红斑狼疮临床活动度降低。肾移植后临床活动度降低最为显著。
