Tawil R, Moxley R T, Griggs R C
Neuromuscular Disease Center, University of Rochester School of Medicine and Dentistry, NY 14642.
Neurology. 1993 Jun;43(6):1105-6. doi: 10.1212/wnl.43.6.1105.
Carbonic anhydrase inhibitors can cause nephrolithiasis. We studied 20 patients receiving long-term carbonic anhydrase inhibitor treatment for periodic paralysis and myotonia. Three patients on acetazolamide (15%) developed renal calculi. Extracorporeal lithotripsy successfully removed a renal calculus in one patient and surgery removed a staghorn calculus in another, permitting continued treatment. Renal function remained normal in all patients. Nephrolithiasis is a complication of acetazolamide but does not preclude its use.
碳酸酐酶抑制剂可导致肾结石。我们研究了20例因周期性麻痹和肌强直而接受长期碳酸酐酶抑制剂治疗的患者。3例服用乙酰唑胺的患者（15%）出现了肾结石。体外冲击波碎石术成功为1例患者清除了肾结石，手术为另1例患者清除了鹿角形结石，从而得以继续治疗。所有患者的肾功能均保持正常。肾结石是乙酰唑胺的一种并发症，但并不妨碍其使用。
