Martinazzi M, Crivelli F, Zampatti C, Martinazzi S
Scuola di Specializzazione in Anatomia Patologica, Università di Pavia.
Pathologica. 1993 Nov-Dec;85(1100):637-44.
The importance of epidermal growth factor receptor (EGF-R) as an immunohistochemical factor of prognosis has been investigated in 820 cases of breast carcinoma irrespective of subtyping. An immunohistochemical membrane positivity for EGF-R (Ab1, clone 455 and Ab2, clone 528, Oncogene Science Manhasset NY, USA, ABC-peroxidase method) has been observed in neoplastic cells of 131/820 breast carcinomas (15.9%); the percentage is lower than those of the majority of reported series, but the total number of cases is higher. A significant inverse relationship between EGF-R and estrogen/progesterone receptors has been found (ER-ICA, PgR-ICA, Abbott, PAP-method). Highly proliferating Ki67 positive (> = 20% stained nuclei-Dakopatts Denmark) and oncoprotein p53 (Pab 1801 clone, Oncogene Science) positive carcinomas are more frequently EGF-R positive (p < 0.001). No relationship exists between EGF-R expression, c-erbB-2 (3B5 clone, Oncogene Science) expression, tumor size and lymph node status. The detection of EGF-R may be a useful addition to other immunohistochemical prognosticators, but it must be related with clinical outcome in further studies.
在820例乳腺癌病例中，无论其亚型如何，均对表皮生长因子受体（EGF-R）作为一种免疫组化预后因子的重要性进行了研究。在820例乳腺癌中的131例（15.9%）肿瘤细胞中观察到EGF-R免疫组化膜阳性（Ab1，克隆号455；Ab2，克隆号528；美国纽约曼哈塞特癌基因科学公司，ABC过氧化物酶法）；该百分比低于大多数报道系列中的百分比，但病例总数更多。已发现EGF-R与雌激素/孕激素受体之间存在显著的负相关关系（ER-ICA，PgR-ICA，雅培公司，PAP法）。高增殖性的Ki67阳性（≥20%染色细胞核，丹麦达科帕茨公司）和癌蛋白p53（克隆号Pab 1801，癌基因科学公司）阳性的癌更常为EGF-R阳性（p<0.001）。EGF-R表达、c-erbB-2（克隆号3B5，癌基因科学公司）表达、肿瘤大小和淋巴结状态之间不存在相关性。EGF-R的检测可能是对其他免疫组化预后指标的有益补充，但在进一步研究中必须将其与临床结果相关联。
