前额叶皮质中假定的含γ-氨基丁酸神经元与锥体神经元之间的功能协同作用。
Functional synergism between putative gamma-aminobutyrate-containing neurons and pyramidal neurons in prefrontal cortex.
作者信息
Wilson F A, O'Scalaidhe S P, Goldman-Rakic P S
机构信息
Section of Neurobiology, Yale University School of Medicine, New Haven, CT 06510.
出版信息
Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):4009-13. doi: 10.1073/pnas.91.9.4009.
Abstract
The responses of putative gamma-aminobutyratergic interneurons (fast-spiking) and pyramidal (regular-spiking) cell pairs were compared in monkeys performing visual and memory-guided oculomotor tasks. Both fast- and regular-spiking neurons had similar receptive fields, indicating that gamma-aminobutyratergic interneurons carry a specific informational signal, as opposed to providing nonspecific modulation. However, the responses of the pairs were inverted and the timing of excitatory and inhibitory responses appeared to be phased, a property consistent with gamma-aminobutyrate-mediated shaping of receptive fields. These observations (i) provide evidence that interneurons and pyramidal cells can be differentiated in vivo and (ii) begin to elucidate the role of gamma-aminobutyratergic mechanisms in cognition.
摘要
在执行视觉和记忆引导的动眼任务的猴子中，对假定的γ-氨基丁酸能中间神经元（快速放电）和锥体（规则放电）细胞对的反应进行了比较。快速放电和规则放电的神经元都具有相似的感受野，这表明γ-氨基丁酸能中间神经元携带特定的信息信号，而不是提供非特异性调制。然而，细胞对的反应是相反的，并且兴奋性和抑制性反应的时间似乎是有相位的，这一特性与γ-氨基丁酸介导的感受野塑造一致。这些观察结果（i）提供了中间神经元和锥体细胞在体内可以区分的证据，（ii）并开始阐明γ-氨基丁酸能机制在认知中的作用。
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