Celio M R
Science. 1986 Feb 28;231(4741):995-7. doi: 10.1126/science.3945815.
gamma-Aminobutyric acid (GABA) is one of the major inhibitory neurotransmitters in the central nervous system. In the cerebral cortex, GABA-containing cells represent a subpopulation of interneurons. With semithin frozen sections, it is possible to demonstrate that most GABA neurons in the rat somatosensory cortex contain the calcium-binding protein parvalbumin and that parvalbumin is found virtually only in GABA neurons. Parvalbumin seems to influence the electrical properties and enzymatic machinery to modulate neuronal excitability and activity. The specific role of parvalbumin in GABA-containing cortical cells may be related to controlling the effectiveness of their inhibitory action.
γ-氨基丁酸（GABA）是中枢神经系统中主要的抑制性神经递质之一。在大脑皮层中，含GABA的细胞代表中间神经元的一个亚群。利用半薄冰冻切片，可以证明大鼠体感皮层中的大多数GABA神经元都含有钙结合蛋白小白蛋白，并且小白蛋白实际上仅存在于GABA神经元中。小白蛋白似乎会影响电特性和酶机制，以调节神经元的兴奋性和活性。小白蛋白在含GABA的皮层细胞中的具体作用可能与控制其抑制作用的有效性有关。
