Casseday J H, Ehrlich D, Covey E
Department of Neurobiology, Duke University Medical Center, Durham, NC 27710.
Science. 1994 May 6;264(5160):847-50. doi: 10.1126/science.8171341.
Duration is a biologically important feature of sound. Some neurons in the inferior colliculus of the big brown bat, Eptesicus fuscus, are tuned to sound duration, but it is unclear at what level the tuning originates or what neural mechanisms are responsible for it. The application of antagonists of the inhibitory neurotransmitters gamma-aminobutyric acid or glycine to neurons in the inferior colliculus eliminated duration tuning. Whole-cell patch-clamp recordings of synaptic currents suggested that inhibition produces a temporal frame within which excitation can occur. A model is proposed in which duration tuning arises when an early, sustained inhibitory input interacts with a delayed, transient excitatory input.
持续时间是声音在生物学上的一个重要特征。大棕蝠（棕蝠）下丘中的一些神经元会对声音持续时间进行调谐，但尚不清楚这种调谐起源于何种水平，以及是哪些神经机制导致了这种调谐。向下丘中的神经元施加抑制性神经递质γ-氨基丁酸或甘氨酸的拮抗剂，会消除持续时间调谐。突触电流的全细胞膜片钳记录表明，抑制作用产生了一个时间框架，在这个框架内可以发生兴奋。本文提出了一个模型，即当早期持续的抑制性输入与延迟的瞬时兴奋性输入相互作用时，就会产生持续时间调谐。
