van de Loo W
MMW Munch Med Wochenschr. 1976 Feb 27;118(9):271-4.
A gastroduodenal combination preparation was introduced at a deliberately high dosage into a clinical treatment schema. A marked improvement of the subjective symptoms already appeared after a short treatment in hospital, pain in particular being rapidly affected. Younger patients tolerated the preparation excellently, older ones had a marked sedation. Because of the danger of concealment, stenoses in the region of the gastrointestinal tract, ileus and preileus are particular contraindications. The dosage of 3 X 3 to 3 X 4 dragees should be reserved for hospital treatment. The dosage of 3 X 1 dragee for ambulant practice and also for prolonged therapy (ca. 6-8 weeks) is unobjectionable, reference being made to possible initial tiredness and disturbances of accomodation.
一种胃十二指肠联合制剂以故意设定的高剂量被引入临床治疗方案。在医院进行短期治疗后，主观症状就已出现明显改善，尤其是疼痛迅速得到缓解。年轻患者对该制剂耐受性良好，老年患者则有明显的镇静作用。由于存在隐匿性风险，胃肠道区域的狭窄、肠梗阻和肠梗阻前期是特别的禁忌证。3×3至3×4片的剂量应留作住院治疗使用。3×1片的剂量用于门诊治疗以及长期治疗（约6 - 8周）是没问题的，但需注意可能出现的初始疲劳和调节障碍。
