Cane M A, Lutman M E, O'Donoghue G M
MRC Institute of Hearing Research, General Hospital, Nottingham, UK.
Am J Otol. 1994 Mar;15(2):207-16.
Transiently evoked otoacoustic emissions (TEOAE) are generally present in ears with normal hearing, but absent in ears with cochlear hearing losses greater than 25-30 dB; they have been demonstrated previously in a few ears with retrocochlear hearing losses greater than 30 dB across the frequency range 0.25-8 kHz. To assess the potential of TEOAEs in the diagnosis of retrocochlear hearing losses, measurements were made in 45 patients with retrocochler disorder attributable to confirmed cerebellopontine angle (CPA) tumors. Transiently evoked OAEs elicited by click stimuli were recordable in 21 (47%) of the ears with tumor. Nine of these had normal hearing at two or more octave frequencies across the range 0.5-4 kHz and so might be expected to have TEOAEs regardless of the type of disorder. The other 12 ears had recordable TEOAEs despite hearing threshold levels greater than 25 dB between 0.5 and 4 kHz. The absence of TEOAEs in the remaining 24 ears (53%) indicated a significant outer hair cell component to the hearing loss. Neither age nor sex were significant factors in the occurrence of TEOAEs. The TEOAE test gives useful differential diagnostic information when emissions are recorded in ears having hearing threshold levels greater than 25 dB at all frequencies. In such ears there is relatively normal cochlear function at the level of the outer hair cells, at least at some frequencies, and hence, by inference, there must be a retrocochlear disorder.
瞬态诱发耳声发射(TEOAE)通常在听力正常的耳朵中出现,但在耳蜗性听力损失大于25 - 30 dB的耳朵中缺失;此前已证实在少数频率范围为0.25 - 8 kHz、蜗后性听力损失大于30 dB的耳朵中存在TEOAE。为评估TEOAE在蜗后性听力损失诊断中的潜力,对45例因确诊的桥小脑角(CPA)肿瘤导致蜗后病变的患者进行了测量。在21只(47%)有肿瘤的耳朵中可记录到由短声刺激诱发的瞬态诱发耳声发射。其中9只耳朵在0.5 - 4 kHz范围内的两个或更多倍频程频率处听力正常,因此无论病变类型如何都可能预期有TEOAE。另外12只耳朵尽管在0.5至4 kHz之间听力阈值水平大于25 dB,但仍可记录到TEOAE。其余24只耳朵(53%)TEOAE缺失表明听力损失中有显著的外毛细胞成分。年龄和性别都不是TEOAE发生的显著因素。当在所有频率听力阈值水平大于25 dB的耳朵中记录到耳声发射时,TEOAE测试可提供有用的鉴别诊断信息。在这样的耳朵中,至少在某些频率下,外毛细胞水平的耳蜗功能相对正常,因此可以推断,必然存在蜗后性病变。