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[瞬态诱发性耳声发射(TEOAE)的特异性和敏感性]

[Specificity and sensitivity of transient click-evoked otoacoustic emissions (TEOAE)].

作者信息

Pröschel U, Eysholdt U

机构信息

Abteilung für Phoniatrie und Pädaudiologie, Univ.-HNO-Klinik Erlangen-Nürnberg.

出版信息

Laryngorhinootologie. 1995 Aug;74(8):481-8. doi: 10.1055/s-2007-997785.

DOI:10.1055/s-2007-997785
PMID:7575899
Abstract

Transient click evoked otoacoustic emissions (TEOAE) have been shown to be a good test of hearing impairment especially when used for infant screening. However, occasional cases of false positive results--TEOAEs in spite of severe hearing loss--have been reported. This study encompasses 243 children whose hearing thresholds were known from subjective hearing tests and--in questionable cases--derived from additional auditory evoked potentials. The TEOAEs proved to have a high sensitivity (93%) and a reasonable specificity (67%), if the margin between good and bad hearing was set at 30 dB. However, four ears showed good TEOAEs in spite of poor hearing thresholds. In three cases, the children proved to have a central auditory hearing loss due to a cerebral disorder. One child with bilaterally superb TEOAEs had a unilateral deafness of unclear origin with no obvious retrocochlear or central disorder. Possible explanations under discussion included the presence of a retrocochlear lesion which was too small to show up in the tests used or that the defect was located just between the outer hair cells and the first neuron, for example in the inner hair cells. Additionally, efferent inhibition might cause a functional deafness as described by Rajan (1989) for the guinea pig. The results also show that TEOAEs should always be used in the differential diagnosis of hearing impairment in generally disabled children. The need for hearing aids and especially their adjustment has to be discussed in case of good TEOAEs, i.e., normal peripheral hearing.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

瞬态诱发耳声发射(TEOAE)已被证明是检测听力损伤的良好方法,尤其适用于婴儿筛查。然而,已有报道称偶尔会出现假阳性结果——尽管听力严重丧失,但TEOAE检测仍呈阳性。本研究纳入了243名儿童,他们的听力阈值通过主观听力测试得知,在有疑问的情况下,则通过额外的听觉诱发电位得出。如果将听力良好与听力不佳的界限设定为30分贝,TEOAE被证明具有较高的敏感性(93%)和合理的特异性(67%)。然而,有4只耳朵尽管听力阈值不佳,但TEOAE检测结果良好。在3例病例中,儿童被证明因脑部疾病导致中枢听觉性听力损失。1名双侧TEOAE检测结果极佳的儿童患有单侧耳聋,病因不明,且无明显的蜗后或中枢性疾病。正在讨论的可能解释包括存在一个蜗后病变,但在所用测试中太小而无法显示,或者缺陷恰好位于外毛细胞和第一神经元之间,例如在内毛细胞中。此外,传出抑制可能会导致功能性耳聋,如Rajan(1989年)对豚鼠所描述的那样。结果还表明,在对一般残疾儿童的听力损伤进行鉴别诊断时,应始终使用TEOAE。如果TEOAE检测结果良好,即外周听力正常,则必须讨论是否需要佩戴助听器,尤其是其调试问题。(摘要截选至250词)

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BMC Med. 2015 May 28;13:125. doi: 10.1186/s12916-015-0366-8.
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[Hearing impairment in children and adolescents with Down's syndrome].[唐氏综合征儿童及青少年的听力障碍]
HNO. 2006 Mar;54(3):227-32. doi: 10.1007/s00106-004-1205-y.
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[Pronounced bilateral mesocochlear hearing impairment from 40-45 dB in spite of regular TEOAE, DPOAE and inconspicuous click-BERA].
HNO. 2004 Jun;52(6):557-60. doi: 10.1007/s00106-004-1068-2.