Ballou W P
Department of Immunology, Walter Reed Army Institute of Research, Washington, District of Columbia.
Am J Trop Med Hyg. 1994;50(4 Suppl):59-65. doi: 10.4269/ajtmh.1994.50.59.
Efficacy trials for malaria blood-stage vaccines are currently underway in several field sites. Numerous issues surround the design and execution of such trials, and there are many opportunities for failure that have little to do with the vaccines per se. This review highlights some of the key issues to be considered by investigators designing such trials, including those that are unique to trials for erythrocytic stage vaccines.
目前，疟疾血液阶段疫苗的疗效试验正在多个实地地点进行。围绕此类试验的设计和实施存在诸多问题，而且存在许多与疫苗本身无关的失败可能性。本综述重点介绍了设计此类试验的研究人员需要考虑的一些关键问题，包括那些红细胞阶段疫苗试验所特有的问题。
