Sant A J, Miller J
Department of Pathology, University of Chicago, Illinois 60637.
Curr Opin Immunol. 1994 Feb;6(1):57-63. doi: 10.1016/0952-7915(94)90034-5.
The invariant chain (Ii) has been shown to play a critical role in the assembly, intracellular transport and function of MHC class II molecules. Recent studies suggest that these distinct activities can in many cases be attributed to distinct isoforms of Ii or to specific regions within it. Thus, regulation of Ii synthesis, post-transcriptional events, and post-translational modification has the potential to dramatically modulate immune responses.
恒定链（Ii）已被证明在MHC II类分子的组装、细胞内运输和功能中起关键作用。最近的研究表明，在许多情况下，这些不同的活性可归因于Ii的不同异构体或其内部的特定区域。因此，对Ii合成、转录后事件和翻译后修饰的调控有可能显著调节免疫反应。
