Hernandez Lopez D, Rivera Hidalgo P, Guedea M S, Rivas y Rivas R M, Gutierrez Samperio C
Prensa Med Mex. 1975 Nov-Dec;40(11-12):346-51.
The purpose of this investigation was the knowledge of certain events related with the intravenous administration of lipids in patients with parenteral nutrition such as tolerance, clearence and changes in the plasmatic lipid fractions and the effect of heparin as capilar lipoprotein-lipase stimulant and of the insulin as lipogenetic hormone. With intralipid the authors observed elevation of serum total lipid, triglicerids and fatty acids; in this patients the fatty acids went up after addition of heparin because triglicerid elucidation but went down after insulin administration which favor the tisular captation of fatty acids. They do not found alteration in serum cholesterol. The results with heparin and insulin suggest a greater and more rapid clearence of plasmatic lipids probably by incorporation of them to the tissues. This feature minimize the risk of exogen hyperlipemia, hyperosmolarity and metabolic acidosis.
本研究的目的是了解与肠外营养患者静脉输注脂质相关的某些事件，如耐受性、清除率以及血浆脂质组分的变化，以及肝素作为毛细血管脂蛋白脂肪酶刺激剂和胰岛素作为脂肪生成激素的作用。作者观察到使用英脱利匹特后血清总脂质、甘油三酯和脂肪酸升高；在这些患者中，添加肝素后脂肪酸升高，因为甘油三酯被清除，但胰岛素给药后脂肪酸下降，这有利于组织对脂肪酸的摄取。他们未发现血清胆固醇有变化。肝素和胰岛素的结果表明，血浆脂质可能通过融入组织而得到更快、更有效的清除。这一特性将外源性高脂血症、高渗性和代谢性酸中毒的风险降至最低。
