Salas Martínez J, Morán Penco J M, Maciá Botejara E, Vinagre Velasco L M
Departamento de Cirugía y Especialidades Médico-Quirúrgicas, Facultad de Medicina, Universidad de Extremadura, España.
Nutr Hosp. 1994 Jan-Feb;9(1):44-53.
To study the morphological and biliary alterations associated with taurine-free parenteral nutrition and its other precursors.
One fed a standard taurine-free amino acid formula, a group fed without taurine or its metabolic precursors, and a control group. At the beginning and end of the experiment, analyses were made of nutritional parameters, hepatic enzymes, biliary composition, plasmatic aminogram and optical and electronic microscopy of the liver.
Significant increases of threonine, glutamine, alanine, lysine, histidine and arginine, and insignificant increases of taurine, serine, isoleucine and leucine in groups with PN. Increased Non-conjugated AB, particularly lithocholic and taurolithocholic acid in groups without taurine precursors. Fat microsteatosis in area 3 of the acinus in the group without taurine, and in the three areas in the group without precursors. Standard taurine-free PN causes changes in the biliary composition and liver histology, which increase in the absence of taurine precursors.
研究与无牛磺酸肠外营养及其其他前体相关的形态学和胆汁改变。
一组喂食标准无牛磺酸氨基酸配方，一组不喂食牛磺酸或其代谢前体，以及一个对照组。在实验开始和结束时，对营养参数、肝酶、胆汁成分、血浆氨基酸谱以及肝脏的光学和电子显微镜进行分析。
接受肠外营养的组中，苏氨酸、谷氨酰胺、丙氨酸、赖氨酸、组氨酸和精氨酸显著增加，牛磺酸、丝氨酸、异亮氨酸和亮氨酸有不显著增加。在没有牛磺酸前体的组中，非结合型AB增加，尤其是石胆酸和牛磺石胆酸。在没有牛磺酸的组中，腺泡3区出现脂肪微脂肪变性，在没有前体的组中，三个区均出现。标准无牛磺酸肠外营养会导致胆汁成分和肝脏组织学发生变化，在没有牛磺酸前体的情况下这种变化会加剧。
