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Immunotherapy of tumor metastasis via gene therapy.

作者信息

Porgador A, Feldman M, Eisenbach L

机构信息

Department of Cell Biology, Weizmann Institute of Science, Rehovot, Israel.

出版信息

Nat Immun. 1994 Mar-Jun;13(2-3):113-30.

PMID:8173233
Abstract

Active cellular immunotherapy of cancer, via gene-modified tumor cells, may develop to an effective treatment modality. Here we discuss some of the cytokines used in gene transfer, the importance of MHC class I expression on tumor cells used as vaccines, the relevance of experimental tumor systems to human tumors, and the use of live versus irradiated vaccines. Possible methods for effective gene transfer and possible protocols for immunotherapy studies are presented. Our studies in two highly metastatic murine tumors, the Lewis lung carcinoma (3LL) and the B16 melanoma, and immune mechanisms involved in immunotherapy of metastasis are summarized.

摘要

相似文献

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Immunotherapy of tumor metastasis via gene therapy.
Nat Immun. 1994 Mar-Jun;13(2-3):113-30.
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Cancers (Basel). 2012 Apr 26;4(2):490-503. doi: 10.3390/cancers4020490.
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Recent advances in the treatment of malignant melanoma with gene therapy.基因治疗在恶性黑色素瘤治疗中的最新进展。
Mol Med. 1997 Oct;3(10):636-51.
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Natural killer cell lines kill autologous beta2-microglobulin-deficient melanoma cells: implications for cancer immunotherapy.自然杀伤细胞系可杀伤自体β2-微球蛋白缺陷的黑色素瘤细胞：对癌症免疫治疗的启示。
Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):13140-5. doi: 10.1073/pnas.94.24.13140.
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Generation of CD8+ T cells specific for transporter associated with antigen processing deficient cells.针对与抗原加工缺陷细胞相关的转运体的CD8 + T细胞的产生。
Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11496-501. doi: 10.1073/pnas.94.21.11496.