Herrup K, Silver J
Alzheimer Research Lab, Case Western Reserve Medical School, Cleveland, Ohio 44106.
Curr Opin Neurobiol. 1994 Feb;4(1):108-11. doi: 10.1016/0959-4388(94)90039-6.
Cortical neurons are organized into highly patterned ensembles of cells, each with a distinct physiological function. The precursors of these cells arise in the ventricular zone, itself a highly patterned mosaic of cells. To determine whether the ventricular pattern presages the adult, investigators examine the process of cell migration. Recent evidence suggests that both radial (pattern-preserving) and tangential (pattern-blurring) cell movements occur during development.
