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急性和长期辐射对大鼠肝脏胶原蛋白的影响。

The effects of acute and long-term irradiation on collagen in rat liver.

作者信息

Ganea E, Vlădescu C, Gheorghe N, Petrescu L

出版信息

Physiologie. 1976 Jan-Mar;13(1):75-81.

PMID:817351
Abstract

The alterations of hepatic collagen were investigated at various periods of time after acute (28 min.) and long-term (11 h) irradiation with 100 R, 250 R, 500 R, 700 R. The amount of total and insoluble collagen increases proportionally with the dose 40 days after irradiation, no such a relationship being apparent in the first days after irradiation. The long-term irradiation with 700 R results in a strong decrease of the amount of each of the collagen fractions, as compared with acute irradiation, tested 4 days after irradiation. The most evident protective effect against irradiation was shown by folcystein, as compared with the other agents administered prior to irradiation with 700 R.

摘要

在急性(28分钟)和长期(11小时)接受100伦琴、250伦琴、500伦琴、700伦琴照射后的不同时间段,对肝脏胶原蛋白的变化进行了研究。照射后40天,总胶原蛋白和不溶性胶原蛋白的量随剂量成比例增加,而在照射后的头几天这种关系并不明显。与照射后4天测试的急性照射相比,700伦琴的长期照射导致每种胶原蛋白组分的量大幅减少。与在700伦琴照射前给予的其他药物相比,半胱氨酸对辐射显示出最明显的保护作用。

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Physiologie. 1976 Jan-Mar;13(1):75-81.
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