交感肾上腺能反应在机体适应+6 Gz加速度作用中的作用。

The role of the sympathoadrenergic reaction in adaptation of the organism to the action of + 6 Gz acceleration.

作者信息

Groza P, Cãrmaciu R, Nicolescu E, Bobic D, Cananău S, Vrãnceanu R

出版信息

Physiologie. 1976 Jan-Mar;13(1):9-18.

Abstract

In experiments on rats the symphathoadrenergic reactivity after a + 6 Gz acceleration was investigated. Hypergravitation produced as a rule a short initial bradycardia, followed by tachycardia. Hexamethonium (C6), a peripheric ganglion-blocking agent, produced bradycardia, diminution or vanishing of the initial bradycardic episode, and a decreased tachycardic reaction. No initial bradycardic response was observed ater atropine. Atropinized and C6-treated rats showed an increased heart frequency response. Centrifugation produced a decreased adrenal catecholamine content and a blood noradrenaline elevation. C6 importantly decreased both catecholamines content in blood. On this background the acceleration produced a slight increase of both blood catecholamines.

摘要

在对大鼠的实验中，研究了 +6 Gz 加速度后的交感肾上腺素能反应性。超重力通常会产生短暂的初始心动过缓，随后是心动过速。六甲铵（C6），一种外周神经节阻断剂，会产生心动过缓、初始心动过缓发作的减轻或消失，以及心动过速反应减弱。阿托品处理后未观察到初始心动过缓反应。用阿托品处理和 C6 处理的大鼠表现出心率反应增加。离心导致肾上腺儿茶酚胺含量降低和血液去甲肾上腺素升高。C6 显著降低了血液中两种儿茶酚胺的含量。在此背景下，加速度使血液中两种儿茶酚胺略有增加。