Competitive in situ hybridization in a mediastinal germ cell tumor.
作者信息
Aly M S, Dal Cin P, Jiskoot P, Deneffe G, Marynen P, Van den Berghe H
机构信息
Center for Human Genetics, University Hospital Gasthuisberg, Belgium.
出版信息
Cancer Genet Cytogenet. 1994 Mar;73(1):53-6. doi: 10.1016/0165-4608(94)90181-3.
PMID:8174074
Abstract
We performed competitive in situ hybridization in a mediastinal germ cell tumor to identify chromosome 12 aberration(s). DNA from a mouse-human somatic hybrid cell line, containing an i(12p) as unique human material, was labeled and used as a probe. Our results confirm that the chromosome marker, observed in mediastinal germ cell tumor and cytogenetically identified as i(12p), is a true isochromosome of the short arm of chromosome 12.
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