二氮嗪逆转血管痉挛的局限性。
Limitations of diazoxide reversal of vasospasm.
作者信息
Heros R C, Lavyne M H, Zervas N T
出版信息
Stroke. 1976 Mar-Apr;7(2):118-20. doi: 10.1161/01.str.7.2.118.
PMID:817424
Abstract
Diazoxide failed to safely relieve cerebral vasospasm by intracisternal injections in dogs and by intracarotid injections in monkeys despite in vitro documentation of arterial relaxation with this agent. Administration of the drug frequently produced hypotension and, in the presence of vasospasm, was associated with a high mortality rate.
摘要
尽管二氮嗪在体外实验中能使动脉舒张，但通过向犬脑池内注射以及向猴颈内动脉注射，该药未能安全地缓解脑血管痉挛。给药时常导致低血压，并且在存在血管痉挛的情况下，死亡率很高。
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