Hamann G F, Isenberg E, Strittmatter M, Stoll M, Keshevar T, Moili R, Schimrigk K
Department of Neurology, University of the Saarland, Homburg, FRG.
Eur Neurol. 1994;34(2):99-102. doi: 10.1159/000117017.
Plasma big endothelin (BE) levels were studied in 17 patients during the first 2 weeks following spontaneous intracerebral hemorrhage (ICH). Three patients had experienced an infratentorial hemorrhage of the pons and cerebellum. The group of 14 patients with supratentorial hemorrhage presented with 8 hematomas of the putamen, 4 of the capsula interna and 2 in the thalamus. Significant elevations of BE during the first 2 weeks after the initial ICH, significant differences between the different localisations and between patients with different prognoses were not apparent (mean BE level: 2.95 +/- 1.39, control group: 2.68 +/- 1.29 fmol/ml). These results support the theory that endothelins do not play a significant pathophysiological role in acute severe ICH.
对17例自发性脑出血（ICH）患者在发病后的前2周内进行了血浆大内皮素（BE）水平研究。3例患者发生了脑桥和小脑幕下出血。14例幕上出血患者中，8例为壳核血肿，4例为内囊血肿，2例为丘脑血肿。在首次脑出血后的前2周内，BE水平未见显著升高，不同部位及不同预后患者之间也无明显差异（平均BE水平：2.95±1.39，对照组：2.68±1.29 fmol/ml）。这些结果支持内皮素在急性重症脑出血中不发挥重要病理生理作用这一理论。
