Meijer O C, de Kloet E R
Leiden/Amsterdam Center for Drug Research, Sylvius Laboratories, The Netherlands.
Eur J Pharmacol. 1994 Feb 15;266(3):255-61. doi: 10.1016/0922-4106(94)90134-1.
The effect of corticosterone on 5-HT1A receptor mRNA expression in different hippocampal cell fields was studied by in situ hybridisation. One week after adrenalectomy or chronic corticosterone treatment, the 5-HT1A receptor mRNA showed a negative, but not linear, correlation with plasma corticosterone levels over a wide concentration range, specifically in the dentate gyrus. The data suggest an involvement of the mineralocorticoid receptor in the regulation of the 5-HT1A receptor mRNA and a possible synergistic effect of additional glucocorticoid receptor activation.
通过原位杂交研究了皮质酮对不同海马细胞区域中5-HT1A受体mRNA表达的影响。肾上腺切除或慢性皮质酮治疗一周后，在很宽的浓度范围内，5-HT1A受体mRNA与血浆皮质酮水平呈负相关，但不是线性相关，特别是在齿状回中。数据表明盐皮质激素受体参与了5-HT1A受体mRNA的调节，以及额外的糖皮质激素受体激活可能产生的协同作用。
