Weidmann S
Physiological Institute, University of Bern, Switzerland.
Experientia. 1994 Apr 15;50(4):342-5. doi: 10.1007/BF02026635.
Fifty years ago, four 'action substances' were described as being 'liberated' from peripheral nerve in the course of activity. An attempt has been made to update this information. Confirmatory evidence is available that acetylcholine and thiamine do play a role in the course of activity. However, the question of the relationship in time between their release and the electrical events, and the possible effect on specific ionic gating mechanisms, remains unclarified. The 'liberation' of potassium has been found to be a transmembrane K efflux, and the question of the existence of another substance similar to thiamine has not been pursued.
五十年前，四种“活性物质”被描述为在神经活动过程中从外周神经“释放”出来。人们曾试图更新这一信息。现有确凿证据表明，乙酰胆碱和硫胺在神经活动过程中确实发挥作用。然而，它们的释放与电活动在时间上的关系问题，以及对特定离子门控机制可能产生的影响，仍未得到阐明。现已发现钾的“释放”是一种跨膜钾外流，而关于是否存在另一种类似于硫胺的物质这一问题尚未深入研究。
