Dodd R Y
American Red Cross, Holland Laboratory, Rockville, MD 20855.
Dev Biol Stand. 1993;81:35-40.
Since the implementation of sensitive screening tests for hepatitis B virus infection, the majority of post-transfusion hepatitis has been due to infection with hepatitis C virus (HCV). The recent introduction of tests for antibodies to this virus has demonstrably reduced the incidence of post-transfusion HCV infection. There is some residual post-transfusion and sporadic hepatitis, which may possibly be caused by an as yet undescribed aetiologic agent. However, evidence for or against such an agent is by no means definitive. The majority of cases of this residual hepatitis seem to be mild and progression to chronicity is less frequent than for HCV infection. There is no evidence to suggest that modern, fully inactivated pooled plasma products transmit this poorly characterized form of hepatitis. However, in some circumstances, the potential for transmission of non-enveloped viruses by clotting factors may persist.
自从实施乙型肝炎病毒感染的敏感筛查试验以来，大多数输血后肝炎是由丙型肝炎病毒（HCV）感染所致。最近引入的针对该病毒抗体的检测已显著降低了输血后HCV感染的发生率。仍存在一些输血后肝炎和散发性肝炎病例，可能是由一种尚未明确的病原体引起的。然而，支持或反对存在这种病原体的证据都不确凿。这种残留肝炎的大多数病例似乎病情较轻，进展为慢性的情况比HCV感染少见。没有证据表明现代的、完全灭活的混合血浆制品会传播这种特征不明的肝炎。然而，在某些情况下，凝血因子传播非包膜病毒的可能性可能依然存在。
