术前放疗对食管鳞状细胞癌DNA倍体的影响。
Influence of preoperative radiotherapy on DNA ploidy in squamous cell carcinomas of the oesophagus.
作者信息
Porschen R, Bevers G, Remy U, Schauseil S, Borchard F
机构信息
Department of Gastroenterology, Heinrich-Heine-University, Düsseldorf, Germany.
出版信息
Gut. 1993 Aug;34(8):1086-90. doi: 10.1136/gut.34.8.1086.
The influence of preoperative radiotherapy on the prevalence of DNA aneuploidy and the prognostic significance of tumour DNA ploidy was evaluated in 126 patients with squamous cell carcinoma of the oesophagus. Preoperative radiotherapy with 30 Gy was performed in 52 patients. DNA ploidy was analysed by flow cytometry on nuclei isolated from paraffin embedded tumour tissue. DNA aneuploidy was identified in 75 tumours (61%) and found to correlate significantly with tumour stage. The percentage of aneuploid carcinomas was significantly reduced by preoperative radiotherapy (surgery only group, 71%; radiotherapy group, 47%, p = 0.01). Although the median survival time was slightly better in the diploid than in the aneuploid group (11.3 and 8.0 months respectively), this difference was not statistically significant. A curative tumour resection was the most important prognostic factor. Preoperative radiotherapy did not prolong survival in oesophageal cancer.
对126例食管鳞状细胞癌患者评估了术前放疗对DNA非整倍体发生率的影响以及肿瘤DNA倍性的预后意义。52例患者接受了30 Gy的术前放疗。通过流式细胞术对从石蜡包埋肿瘤组织中分离的细胞核进行DNA倍性分析。在75个肿瘤（61%）中鉴定出DNA非整倍体，发现其与肿瘤分期显著相关。术前放疗显著降低了非整倍体癌的比例（单纯手术组为71%；放疗组为47%，p = 0.01）。尽管二倍体组的中位生存时间略长于非整倍体组（分别为11.3个月和8.0个月），但这种差异无统计学意义。根治性肿瘤切除是最重要的预后因素。术前放疗并未延长食管癌患者的生存期。
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