Ueki H
Department of Dermatology Kawaski Medical School, Kurashiki.
Hautarzt. 1994 Mar;45(3):154-60. doi: 10.1007/s001050050055.
In several cases of lupus erythematosus (SLE, SCLE, DLE), the Koebner phenomenon could be seen in the apparently normal skin of patients following traumas, scratching effects, operation scars, contact dermatitis, pressure from sock tops, application of liquid nitrogen, exposure to strong sun light, etc. The interval between exposure to such provocation factors and appearance of the isomorphic reactions varied from case to case. In SLE patients receiving systemic treatment with glucocorticosteroids, the Koebner phenomenon could not be found, while it was detected in patients with generalized DLE who had never received any systemic glucocorticoid hormones. It was not seen in patients with localized DLE. There was no direct relationship between the appearance of humoral autoantibodies and onset of the Koebner phenomenon. With regard to the histopathogenesis of the Koebner phenomenon, it is thought that disturbances of the local cellular repair processes and of the cytokine network, with expression of adhesion molecules, might be involved. The Koebner phenomenon may be a valuable model for the investigation of lupus erythematosus.
在几例红斑狼疮（系统性红斑狼疮、亚急性皮肤型红斑狼疮、盘状红斑狼疮）中，在创伤、搔抓、手术瘢痕、接触性皮炎、袜口压力、液氮涂抹、强烈阳光照射等之后，患者看似正常的皮肤中可出现同形反应。接触此类诱发因素与同形反应出现之间的间隔因病例而异。接受糖皮质激素全身治疗的系统性红斑狼疮患者未发现同形反应，而在从未接受过任何全身糖皮质激素治疗的泛发性盘状红斑狼疮患者中检测到了同形反应。局限性盘状红斑狼疮患者未出现同形反应。体液自身抗体的出现与同形反应的发生之间无直接关系。关于同形反应的组织病理发生机制，认为可能涉及局部细胞修复过程和细胞因子网络的紊乱以及黏附分子的表达。同形反应可能是研究红斑狼疮的一个有价值的模型。
