BE-23372M，一种新型蛋白酪氨酸激酶抑制剂。III. 合成。

BE-23372M, a novel protein tyrosine kinase inhibitor. III. Synthesis.

作者信息

Tanaka S, Okabe T, Nakajima S, Yoshida E, Morishima H

机构信息

Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd., Japan.

出版信息

J Antibiot (Tokyo). 1994 Mar;47(3):297-300. doi: 10.7164/antibiotics.47.297.

DOI:10.7164/antibiotics.47.297

PMID:8175482

Abstract

In a preceding paper, the physico-chemical properties and structural elucidation of BE-23372M, a potent novel protein tyrosine kinase inhibitor, were described. In this paper, we report the synthesis of BE-23372M from 3-(3,4-dimethoxybenzoyl)propionic acid and veratraldehyde or 3,4-diacetoxy-benzaldehyde. The structure of BE-23372M was confirmed to be (E)-3-(3,4-dihydroxybenzylidene)-5-(3,4-dihydroxyphenyl)-2(3H)-fur anone.

摘要

在前一篇论文中，描述了一种强效新型蛋白酪氨酸激酶抑制剂BE - 23372M的物理化学性质和结构解析。在本文中，我们报道了由3-(3,4 - 二甲氧基苯甲酰基)丙酸与藜芦醛或3,4 - 二乙酰氧基苯甲醛合成BE - 23372M的方法。BE - 23372M的结构经确认为(E)-3-(3,4 - 二羟基亚苄基)-5-(3,4 - 二羟基苯基)-2(3H)-呋喃酮。