BE-23372M，一种新型蛋白酪氨酸激酶抑制剂。II. 物理化学性质及结构解析。

BE-23372M, a novel protein tyrosine kinase inhibitor. II. Physico-chemical properties and structure elucidation.

作者信息

Tanaka S, Okabe T, Nakajima S, Yoshida E, Suda H

机构信息

Tsukuba Research Institute, Banyu Pharmaceutical Co., Ltd., Japan.

出版信息

J Antibiot (Tokyo). 1994 Mar;47(3):294-6. doi: 10.7164/antibiotics.47.294.

DOI:10.7164/antibiotics.47.294

PMID:8175481

Abstract

BE-23372M, a new protein tyrosine kinase inhibitor, has been obtained as a reddish orange solid. The compound, C17H12O6, HRFAB-MS: m/z 312.0625 (M)+, is an acidic substance, showing UV (MeOH) lambda max (epsilon) 266 (8,800), 426 nm (20,400), and IR (KBr)vmax 1752(C = O) and 3298(OH) cm-1. The structure of BE-23372M, (E)-3-(3,4-dihydroxybenzylidene)-5-(3,4-dihydroxyphenyl)-2(3H)-fur anone, has been elucidated by 1H and 13C NMR studies.

摘要

BE-23372M是一种新型蛋白酪氨酸激酶抑制剂，呈红橙色固体。该化合物化学式为C17H12O6，高分辨快原子轰击质谱（HRFAB-MS）：m/z 312.0625（M）+，是一种酸性物质，其紫外光谱（甲醇溶液）最大吸收波长λmax（ε）为266（8800）、426纳米（20400），红外光谱（溴化钾压片）波数vmax为1752（C = O）和3298（OH）厘米-1。通过1H和13C核磁共振研究确定了BE-23372M的结构为（E）-3-（3,4-二羟基亚苄基）-5-（3,4-二羟基苯基）-2（3H）-呋喃酮。