Sourander P, Sima A, Schucht H
Acta Neurol Scand. 1976 Mar;53(3):209-16. doi: 10.1111/j.1600-0404.1976.tb04339.x.
Changes in the RNA-content of isolated anterior horn motor neurons from the 7th cervical segment were studied during the postnatal development of pre- and postnatally undernourished, and normally nourished rats. The motor neurons of the anterior horn were isolated by micromanipulation from Carnoy-fixed sections. The neuronal RNA-content was determined by microchemical methods according to Edström (1964). The observation was made that moderate pre- and postnatal undernutrition does not alter the normal RNA-accumulation in anterior horn motor neurons during the preweaning period. After weaning the cellular RNA incorporation decreases but again reaches normal values at the age of 39 days. The present results are compared with those of a previous study (Haltia 1970) in which rats were severely undernourished postnatally.
在出生前和出生后营养不良以及正常营养的大鼠出生后发育过程中，研究了从第7颈段分离出的前角运动神经元的RNA含量变化。通过显微操作从Carnoy固定切片中分离出前角运动神经元。根据埃德斯托姆（1964年）的方法，用微量化学方法测定神经元的RNA含量。观察到出生前和出生后适度营养不良不会改变断奶前时期前角运动神经元中正常的RNA积累。断奶后细胞RNA掺入减少，但在39日龄时再次达到正常值。将本研究结果与先前一项研究（哈尔蒂亚，1970年）的结果进行了比较，在该研究中，大鼠出生后严重营养不良。
