Shimi I R, Shoukry S, Zaki Z
Antimicrob Agents Chemother. 1976 Apr;9(4):580-4. doi: 10.1128/AAC.9.4.580.
4,4'-Isopropylidine-bis[2-isopropyl]phenol was found to possess antimicrobial activity against gram-positive bacteria and some fungi, whereas it had no effect on gram-negative organisms. The drug has a potent inhibitory action on the synthesis of cell wall mucopeptides of Bacillus subtilis by inhibiting the enzyme d-glutamate ligase, which is responsible for the incorporation of d-glutamic acid into uridine 5'-diphosphate-muramyl-l-alanine. The drug had a weak lytic effect on protoplasts and inhibited protein synthesis, whereas no significant effect on the synthesis of deoxyribonucleic acid and ribonucleic acid was found.
4,4'-亚异丙基双[2-异丙基]苯酚被发现对革兰氏阳性菌和一些真菌具有抗菌活性，而对革兰氏阴性菌没有作用。该药物通过抑制d-谷氨酸连接酶对枯草芽孢杆菌细胞壁粘肽的合成具有强效抑制作用，d-谷氨酸连接酶负责将d-谷氨酸掺入尿苷5'-二磷酸-胞壁酰-l-丙氨酸。该药物对原生质体有较弱的溶解作用并抑制蛋白质合成，而对脱氧核糖核酸和核糖核酸的合成未发现显著影响。
