Maccherini M, Davoli G, Sani G, Miraldi F, Gotti G, Toscano M
Istituto di Chirurgia Toracica e Cardiovascolare, Ospedale Le Scotte, Università degli Studi di Siena.
Minerva Chir. 1993 Dec;48(23-24):1445-8.
The immunodepressive effect of surgical procedures is well known. Immunotherapy with thymic hormones has used a long time to prevent surgical immunitary damage. In cardiac surgery, we can observe a hard immunitary depression caused by the cardiopulmonary bypass (CBP). In this paper we evaluate the response to immunotherapy, with an extractive thymic hormone: thymostimulin at the dosage of 1 mg/kg/day; 20 patients of a group of 40 underwent CBP. Immunological monitoring was obtained with the "multitest CMI", a disposable skin test to evaluate changes of lymphocytes, especially T cells. Results shows a significant increase of response in patients treated with thymostimulin versus control. A larger sample and a deeper immunitary assessment will be provided in the future.
外科手术的免疫抑制作用是众所周知的。胸腺激素免疫疗法长期以来一直被用于预防手术引起的免疫损伤。在心脏手术中，我们可以观察到体外循环（CBP）导致的严重免疫抑制。在本文中，我们评估了用一种提取的胸腺激素：剂量为1毫克/千克/天的胸腺刺激素进行免疫治疗的效果；40名患者中有20名接受了CBP。通过“多测试CMI”进行免疫监测，这是一种一次性皮肤试验，用于评估淋巴细胞尤其是T细胞的变化。结果显示，与对照组相比，接受胸腺刺激素治疗的患者反应显著增加。未来将提供更大的样本和更深入的免疫评估。
