Mariette X, Tsapis A, Brouet J C
Laboratory of Immunopathology, Hôpital Saint Louis, Paris, France.
Nouv Rev Fr Hematol (1978). 1994;36 Suppl 1:S95-8.
Nucleotide sequences of variable regions of autoantibodies may help to understand the origin of B cells secreting autoantibodies, both in the context of monoclonal lymphoid proliferations and polyclonal autoimmune diseases. We established the nucleotide sequence of variable genes of four monoclonal IgM secreted by lymphoplasmacytic proliferations and directed to myelin-associated glycoprotein, of five anti-lamin B autoantibodies in patients with a lupus like vasculitis, and of one monoclonal IgM secreted in a chronic lymphocytic leukemia patient and directed to the cardiolipin/beta 2 glycoprotein I complex. A selection process (antigen-driven?) was probably implicated in the origin of autoantibodies in the first two situations although a random process occurred in the last one.
自身抗体可变区的核苷酸序列可能有助于理解分泌自身抗体的B细胞的起源，无论是在单克隆淋巴细胞增殖还是多克隆自身免疫性疾病的背景下。我们确定了由淋巴浆细胞增殖分泌并针对髓鞘相关糖蛋白的四种单克隆IgM、狼疮样血管炎患者的五种抗核纤层蛋白B自身抗体以及一名慢性淋巴细胞白血病患者分泌并针对心磷脂/β2糖蛋白I复合物的一种单克隆IgM的可变基因的核苷酸序列。在前两种情况下，自身抗体的产生可能涉及一个选择过程（抗原驱动？），尽管在最后一种情况下发生的是随机过程。
