[Origin of gustatory alliesthesia: comparison of oral glucose or protein-lipid loads].

The gustative pleasure evoked by sweet stimuli has been evaluated before and after an oral load of glucose or a lipido-protidic meal without carbohydrates in human subjects in weight balance. The pleasure is decreased (negative alliesthesia) after each of the ingestions.The negative alliesthesia for sweet stimuli is therefore not only a consequence of carbohydrate ingestion but it appears also when other nutriments, mainly proteins or their degradation products, are present in the intestinal tract. These data strongly support the view that the gustative alliesthesia may be connected with short term satiety. The mechanism of gustative alliesthesia is partially unknown; the data presented here suggest the participation of intestinal chemoreceptors specific for amino acids.