Brkovic D, Riedasch G, Waldherr R, Röhl L, Staehler G
Urologische Universitätsklinik und Poliklinik Heidelberg.
Urologe A. 1994 Mar;33(2):104-9.
Although excellent survival rates for nephron-sparing surgery in mandatory indications (solitary kidney, bilateral renal neoplasms) have been documented, parenchymasparing surgery in elective indications (normal contralateral kidney) is a point of controversy. Local tumor recurrence is the most important argument against this approach. From January 1971 to December 1989, 107 patients suffering from renal cell carcinoma in solitary kidneys or bilateral renal carcinoma underwent nephron-sparing surgery. Thirteen patients (12%) suffered from local recurrence between 4 and 112 months after tumor resection. A high proportion of these recurrences were seen within the first 2 years after resection, followed by a almost linear increase thereafter. Thus-there are possibly two different entities for local recurrence. A correlation between tumor grade and interval from resection to local recurrence could be found, with a long average interval for grade 1 tumors--longer than the published follow-up times for patients undergoing elective tumor resections. Although most of the patients described in this report do not fulfil the surgical criteria for elective resection, we cannot recommend parenchyma-sparing surgery in elective indications.
尽管已有文献记载,对于强制性适应症(孤立肾、双侧肾肿瘤)的保肾手术有着出色的生存率,但对于选择性适应症(对侧肾正常)的实质保留手术仍存在争议。局部肿瘤复发是反对这种手术方式的最重要论据。从1971年1月至1989年12月,107例患有孤立肾肾细胞癌或双侧肾癌的患者接受了保肾手术。13例患者(12%)在肿瘤切除后4至112个月出现局部复发。这些复发中有很大一部分出现在切除后的头2年内,此后几乎呈线性增加。因此,局部复发可能存在两种不同的情况。可以发现肿瘤分级与从切除到局部复发的时间间隔之间存在相关性,1级肿瘤的平均间隔时间较长——比接受选择性肿瘤切除患者已公布的随访时间还要长。尽管本报告中描述的大多数患者不符合选择性切除的手术标准,但我们不建议在选择性适应症中进行实质保留手术。