顺式衣壳化信号的茎环结构在自然发生的乙型肝炎病毒变体中高度保守。
The stem-loop structure of the cis-encapsidation signal is highly conserved in naturally occurring hepatitis B virus variants.
作者信息
Laskus T, Rakela J, Persing D H
机构信息
Department of Experimental Pathology and Laboratory Medicine, Mayo Clinic, Rochester, Minnesota 55905.
出版信息
Virology. 1994 May 1;200(2):809-12. doi: 10.1006/viro.1994.1247.
PMID:8178463
Abstract
The region encoding the stem-loop structure of the HBV cis-encapsidation signal was sequenced in 87 patients with various forms of hepatitis. Altogether, 20 nucleotide substitutions were found; 15/20 were predicted to increase the stability of the stem-loop structure. Substitutions likely to decrease the stability of the cis-encapsidation signal were not observed.
摘要
对87例不同类型肝炎患者的乙肝病毒顺式包装信号茎环结构编码区进行了测序。共发现20个核苷酸替换；其中15/20个预计会增加茎环结构的稳定性。未观察到可能降低顺式包装信号稳定性的替换。
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