Lieback E, Meyer R, Nawrocki M, Bellach J, Hetzer R
German Heart Institute, Berlin.
Ann Thorac Surg. 1994 May;57(5):1164-70. doi: 10.1016/0003-4975(94)91348-x.
Ultrasonic tissue characterization is based on the assumption that microscopic tissue structures are identifiable by their acoustic properties. Our study group consisted of 23 cardiac recipients. Two-dimensional images were obtained within 2 hours of endomyocardial biopsy. The end-diastolic echo frames were digitized into the matrix of an image-processing system. A region of interest was placed into the anteroseptal segment of the left ventricle. The texture within the region of interest was analyzed using four major groups of texture analysis (first-order histogram, co-occurrence matrix, run-length statistic, and power spectrum). A total of 408 echocardiographic examinations were compared with histologic findings. The 117 initially calculated texture parameters were reduced incrementally using a series of discriminant analyses. A set of three texture parameters (inverse difference moment undirected, run-length nonuniformity vertical, and sector sum) was able to describe changed echocardiographic texture when rejection occurred. Using these three parameters, echocardiographic sensitivity was 89.0% and specificity was 83.6% for moderate rejection. We conclude that cardiac rejection is associated with echocardiographic texture alterations and that serial echocardiographic texture analysis can reliably identify rejection.
超声组织特征分析基于这样一种假设，即微观组织结构可通过其声学特性来识别。我们的研究组由23名心脏移植受者组成。在心肌内膜活检后2小时内获取二维图像。舒张末期回声帧被数字化到图像处理系统的矩阵中。在左心室前间隔段放置一个感兴趣区。使用四类主要的纹理分析（一阶直方图、共生矩阵、游程统计和功率谱）对感兴趣区内的纹理进行分析。总共408次超声心动图检查与组织学结果进行了比较。最初计算的117个纹理参数通过一系列判别分析逐步减少。一组三个纹理参数（无向逆差矩、垂直游程不均匀性和扇区总和）能够描述排斥反应发生时超声心动图纹理的变化。使用这三个参数，对于中度排斥反应，超声心动图的敏感性为89.0%，特异性为83.6%。我们得出结论，心脏排斥反应与超声心动图纹理改变有关，并且连续的超声心动图纹理分析能够可靠地识别排斥反应。
