Watanabe T K, Yamazaki T
Genetics. 1976 Apr;82(4):697-702. doi: 10.1093/genetics/82.4.697.
Through examination of all available data on lethal and inversion frequencies on the second chromosome in natural populations of Drosophila melanogaster, we have discovered that there is a clear negative correlation between the two quantities. Lethal genes are located more densely on the regions of standard gene arrangement than the inverted regions, and this accounts for the negative correlation. To reveal the underlying mechanism of the phenomena, we have carried out an experiment and found that effect of EMS-induced mutations on the inversion-carrying chromosome is more severe than that on the standard chromosome. We interpret these results as evidence for coadaptation or position-effect within the inversion chromosomes. New mutations within the coadapted gene complex are quickly eliminated from the population and polymorphic inversions are kept free of mutants through selective elimination.
通过检查黑腹果蝇自然种群中第二条染色体上致死基因和倒位频率的所有可用数据，我们发现这两个数量之间存在明显的负相关。致死基因在标准基因排列区域比倒位区域分布更密集，这就解释了这种负相关。为了揭示这种现象的潜在机制，我们进行了一项实验，发现EMS诱导的突变对携带倒位的染色体的影响比对标准染色体的影响更严重。我们将这些结果解释为倒位染色体内共适应或位置效应的证据。共适应基因复合体中的新突变会迅速从种群中消除，多态倒位通过选择性消除而保持无突变状态。
