Choi Y C, Lee M S, Choi I S
Department of Neurology, Youngdong Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
J Korean Med Sci. 1993 Dec;8(6):476-81. doi: 10.3346/jkms.1993.8.6.476.
The delayed-onset focal dystonia is a rare sequela of cerebrovascular disease or diffuse cerebral hypoxic damage. The responsible lesion sites for the dystonia are variable and the pathogenesis is uncertain. We describe two children with delayed-onset focal dystonia as a complication of perinatal anoxia. The intervals between hypoxic insult and onset of dystonia were 6 years in one and 3 in the other cases. Our patients did not have a focal lesion; one had scattered white matter lesion and the other had a diffuse frontoparietal atrophy. Delayed-onset dystonia after perinatal anoxia can be also caused by non-focal lesion such as diffuse frontoparietal atrophy or cerebral white matter lesion with long interval delay.
迟发性局灶性肌张力障碍是脑血管疾病或弥漫性脑缺氧损伤的一种罕见后遗症。肌张力障碍的责任病灶部位各不相同，发病机制尚不确定。我们描述了两名患有迟发性局灶性肌张力障碍的儿童，这是围产期缺氧的一种并发症。一例患者缺氧损伤至肌张力障碍发作的间隔为6年，另一例为3年。我们的患者没有局灶性病变；一例有散在的白质病变，另一例有弥漫性额顶叶萎缩。围产期缺氧后的迟发性肌张力障碍也可能由非局灶性病变引起，如弥漫性额顶叶萎缩或间隔时间较长的脑白质病变。
