Vogel K S
Molecular Embryology Section; NCI-Frederick Cancer Research and Development Center; ABL-Basic Research Program, MD 21702-1201.
Mol Neurobiol. 1993 Fall-Winter;7(3-4):363-82. doi: 10.1007/BF02769183.
During embryogenesis, the neurons of vertebrate sympathetic and sensory ganglia become dependent on neurotrophic factors, derived from their targets, for survival and maintenance of differentiated functions. Many of these interactions are mediated by the neurotrophins NGF, BDNF, and NT3 and the receptor tyrosine kinases encoded by genes of the trk family. Both sympathetic and sensory neurons undergo developmental changes in their responsiveness to NGF, the first neurotrophin to be identified and characterized. Subpopulations of sensory neurons do not require NGF for survival, but respond instead to BDNF or NT3 with enhanced survival. In addition to their classic effects on neuron survival, neurotrophins influence the differentiation and proliferation of neural crest-derived neuronal precursors. In both sympathetic and sensory systems, production of neurotrophins by target cells and expression of neurotrophin receptors by neurons are correlated temporally and spatially with innervation patterns. In vitro, embryonic sympathetic neurons require exposure to environmental cues, such as basic FGF and retinoic acid to acquire neurotrophin-responsiveness; in contrast, embryonic sensory neurons acquire neurotrophin-responsiveness on schedule in the absence of these molecules.
在胚胎发生过程中，脊椎动物交感神经节和感觉神经节的神经元变得依赖于源自其靶标的神经营养因子来维持生存和分化功能。这些相互作用中的许多是由神经营养蛋白NGF、BDNF和NT3以及trk家族基因编码的受体酪氨酸激酶介导的。交感神经元和感觉神经元对最早被鉴定和表征的神经营养蛋白NGF的反应性都会经历发育变化。感觉神经元亚群的存活不需要NGF，而是对BDNF或NT3有反应，其存活能力增强。除了对神经元存活的经典作用外，神经营养蛋白还影响神经嵴衍生的神经元前体的分化和增殖。在交感和感觉系统中，靶细胞产生神经营养蛋白以及神经元表达神经营养蛋白受体在时间和空间上都与神经支配模式相关。在体外，胚胎交感神经元需要暴露于环境信号，如碱性成纤维细胞生长因子和视黄酸，以获得对神经营养蛋白的反应性；相反，胚胎感觉神经元在没有这些分子的情况下会按时获得对神经营养蛋白的反应性。
