Smith M O, Sutjipto S, Lackner A A
California Regional Primate Research Center, University of California at Davis 95616.
AIDS Res Hum Retroviruses. 1994 Jan;10(1):81-9. doi: 10.1089/aid.1994.10.81.
We examined cerebrospinal fluid (CSF) and serum from 25 simian immunodeficiency (SIV)-infected rhesus macaques for the presence of SIV-specific immunoglobulin G (IgG) and for intrathecal synthesis of IgG. SIV-specific IgG was present in CSF from almost 50% of the macaques. In approximately half of these animals the SIV-specific IgG appeared to be derived from serum by leakage across a disrupted blood-brain barrier, whereas in the remaining animals there was evidence of intrathecal IgG synthesis. There were no significant associations between CSF SIV-specific IgG, intrathecal IgG synthesis and isolation of virus from CSF, clinical status, or neuropathological findings. However, SIV-specific IgG was absent from CSF in all four of the macaques with SIV encephalitis. The presence of SIV-specific IgG in CSF may have a modulating effect on the development of SIV-associated neurological disease.
我们检测了25只感染猿猴免疫缺陷病毒（SIV）的恒河猴的脑脊液（CSF）和血清，以检测SIV特异性免疫球蛋白G（IgG）的存在情况以及IgG的鞘内合成情况。近50%的猕猴脑脊液中存在SIV特异性IgG。在这些动物中，约一半的SIV特异性IgG似乎是通过破损的血脑屏障渗漏自血清，而在其余动物中，则有鞘内IgG合成的证据。脑脊液中SIV特异性IgG、鞘内IgG合成与从脑脊液中分离病毒、临床状态或神经病理学发现之间无显著关联。然而，所有4只患有SIV脑炎的猕猴脑脊液中均未检测到SIV特异性IgG。脑脊液中SIV特异性IgG的存在可能对SIV相关神经疾病的发展具有调节作用。
