von Herrath M, Oldstone M B, Fox H S
Department of Neuropharmacology, Scripps Research Institute, La Jolla, CA 92037, USA.
J Immunol. 1995 May 15;154(10):5582-9.
Simian immunodeficiency virus (SIV)-specific CD8+ CTL were isolated from blood, cerebrospinal fluid, and brains of rhesus macaques infected i.v. with SIV. CTL were found as early as 1 wk postinfection and their appearance correlated with a decrease of viral Ag (p27) found in the blood. CTL isolated from cerebrospinal fluid and/or brain often recognized different viral proteins than CTL isolated from blood, suggesting either a unique migratory pattern to the central nervous system or a difference in activation/retention of lymphocytes in these compartments.
从静脉注射感染猴免疫缺陷病毒（SIV）的恒河猴的血液、脑脊液和大脑中分离出了SIV特异性CD8 + 细胞毒性T淋巴细胞（CTL）。早在感染后1周就发现了CTL，其出现与血液中病毒抗原（p27）的减少相关。从脑脊液和/或大脑中分离出的CTL通常识别与从血液中分离出的CTL不同的病毒蛋白，这表明要么存在一种独特的向中枢神经系统的迁移模式，要么这些隔室中淋巴细胞的激活/滞留存在差异。
