与真性红细胞增多症相关的过敏性紫癜性肾炎。

Henoch-Schönlein purpura nephritis associated with polycythemia vera.

作者信息

Kanauchi M, Dohi K, Shiiki H, Fujii Y, Ishikawa H

机构信息

First Department of Internal Medicine, Nara Medical University.

出版信息

Intern Med. 1994 Jan;33(1):36-40. doi: 10.2169/internalmedicine.33.36.

DOI:10.2169/internalmedicine.33.36

PMID:8180441

Abstract

We present a 53-year-old man with rapidly progressive glomerulonephritis and Henoch-Schönlein purpura which developed during the course of treatment for polycythemia vera. An initial renal biopsy specimen showed mesangial proliferative glomerulonephritis. The patient was admitted to the hospital with cutaneous purpura and progressive renal failure after having received 700 mg of ranimustine over a 29 month period as therapy for the polycythemia vera. A second renal biopsy specimen revealed crescentic glomerulonephritis with deposition of immunofluorescent IgA. These data suggest that Henoch-Schönlein purpura nephritis may occur in response to ranimustine therapy.

摘要

我们报告一名53岁男性，其在真性红细胞增多症的治疗过程中并发了快速进展性肾小球肾炎和过敏性紫癜。最初的肾活检标本显示为系膜增生性肾小球肾炎。该患者在接受了29个月共700mg雷莫司汀治疗真性红细胞增多症后，因皮肤紫癜和进行性肾衰竭入院。第二次肾活检标本显示为新月体性肾小球肾炎，伴有免疫荧光IgA沉积。这些数据提示过敏性紫癜性肾炎可能是雷莫司汀治疗的不良反应。