Valente G, Vercellino V, Corradi L, Tardy A, Bertetto O, Pomatto E, Palestro G
Dipartimento Scienze Biomediche e Oncologia Umana, Torino, Italy.
Eur J Cancer B Oral Oncol. 1993 Apr;29B(2):113-7. doi: 10.1016/0964-1955(93)90032-a.
Serial sections of whole surgical specimens from 28 patients with locally advanced oral carcinoma were examined to assess the histopathological effects of a preoperative intravenous (i.v.) chemotherapy and radiotherapy protocol. In 15 cases (54%), no residual neoplastic tissue was found: in 9, the tumour area showed a dense hyalinised connective tissue, whereas in the other 6 cases foci of keratotic material were surrounded by a foreign body-type reaction. In 13 patients (46%), residual neoplastic tissue was observed: small fields of tumour were present in 6 cases, whereas tumour was widely persistent in 7. Lymph node metastases were observed in 9 cases (32%), with extracapsular spreading in 6 (21%). In 93% of cases, pathological staging on the specimen was more favourable than the clinical preoperative staging. 23 patients (82%) are alive without evidence of disease 30-55 months after surgery; 10 (43%) did not show any residual neoplastic tissue in the specimen; 10 patients (43%) showed persistence of tumour, but in 5 (21%) only small fields of tumour were observed. 4 patients (14%) died due to their tumour. The pathological data show that this protocol is successful in the treatment of advanced oral carcinoma; furthermore, they provide reliable information about the response to therapy and the subsequent course of the disease.
对28例局部晚期口腔癌患者手术切除的完整标本进行连续切片检查，以评估术前静脉化疗和放疗方案的组织病理学效果。15例（54%）未发现残留肿瘤组织：9例中，肿瘤区域显示致密的玻璃样变结缔组织，而其他6例中，角化物质灶被异物型反应包围。13例（46%）观察到残留肿瘤组织：6例存在小面积肿瘤，7例肿瘤广泛残留。9例（32%）观察到淋巴结转移，6例（21%）有包膜外扩散。93%的病例中，标本的病理分期比术前临床分期更乐观。23例（82%）患者术后30 - 55个月存活且无疾病证据；10例（43%）标本中未显示任何残留肿瘤组织；10例（43%）显示肿瘤残留，但其中5例（21%）仅观察到小面积肿瘤。4例（14%）患者死于肿瘤。病理数据表明该方案在晚期口腔癌治疗中是成功的；此外，它们提供了有关治疗反应和疾病后续进程的可靠信息。
